-344-ESTIMATION OF PULMONARY EXTRAVASCULAR WATER VOLUME WITH DOUBLE INDICATOR DILUTION METHOD, USING HEAT AND DYE : INFLUENCE OF RESPONSE TIME ON SHAPE OF INDICATOR DILUTION CURVE

Estimation of extravascular lung water by indicator-dilution techniques.

Indicator dilution measurements of extravascular water in the lungs.

Multiple indicator dilution studies of the pulmonary circulation were carried out in conscious, resting and exercising, and anesthetized dogs under conditions where there was no pulmonary edema. Labeled red cells, water, and albumin were injected together into the pulmonary artery, and effluent dilution patterns were obtained from the descending thoracic aorta. The product of the mean transit t...

Reproducibility of double indicator dilution measurements of intrathoracic blood volume compartments, extravascular lung water, and liver function.

STUDY OBJECTIVE Arterial thermal dye dilution (TDDart) with the COLD system (Munich, Germany) allows measurement of cardiac index (CI), partial blood volumes, lung water, and liver function. The aim of the study was to determine agreement of TDDart measurements with pulmonary artery thermal dilution measurements (TDpa) and to assess the reproducibility of TDDart parameters. DESIGN Prospective...

Thermal dye double indicator dilution measurement of lung water in man: comparison with gravimetric measurements.

The thermal dye double indicator dilution technique for estimating lung water was compared with gravimetric analyses in nine human subjects who were organ donors. As observed in animal studies, the thermal dye measurement of extravascular thermal volume (EVTV) consistently overestimated gravimetric extravascular lung water (EVLW), the mean (SEM) difference being 3.43 (0.59) ml/kg. In eight of t...

Time and Concentration Components of Indicator-Dilution

T HE RECORDING of concentration-time curves at a peripheral arterial site following injection of an indicator into the heart and great vessels provides a valuable tool for the study of normal and abnormal circulation. Its increasing use in diagnostic and research laboratories attests to its efficacy. When this technic is used, it is desirable to have a normal standard of reference with which th...